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Alfonso Franciosi (Elettra Sincrotrone Trieste), Salvatore La Rosa (AREA Science Park)7/3/23, 9:00 AM
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Maurizio Polentarutti (Elettra Sincrotrone Trieste)7/3/23, 9:20 AM
After 27 years of successfully serving the user community, Elettra is undertaking a major upgrade towards a diffraction limited light source, called Elettra 2.0, enabling new science and the development of new technologies to the general benefit.
Due to a substantial reduction of the emittance of the stored electron beam, the new machine will be able to host in particular also in-vacuum...
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Nicola Demitri (Elettra Sincrotrone Trieste)7/3/23, 9:40 AM
The new high brilliance microfocus μXRD beamline will be presented. μXRD aims to fullfill the needs of current XRD2 community and will open new opportunities to Elettra MX users.
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Martin Savko (SOLEIL)7/3/23, 10:00 AM
The best thing one can do to determine the structure of a biological macromolecule at atomic resolution is to grow a large homogeneous crystal of it, then probe it with flat X-ray beam of the matching size, while rotating it using a perfect goniometer while measuring the complete reciprocal image of its electronic density with a perfect detector.
Though this ideal is not feasible in...
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Daniele de Sanctis (ESRF)7/3/23, 11:00 AM
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Ailsa Powell (Diamond Light Source)7/3/23, 11:30 AM
i04-1 at Diamond Light Source is a fixed wavelength, high throughput beamline, dedicated to running unattended data collection queues. We utilise the beamtime to run XChem fragment screening experiments for both industry and academic users, allowing us on average to collect 2000 samples per week. In addition to what we require from the beamline, this talk will focus on the infrastructure...
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Roberto Pugliese (Elettra)7/3/23, 12:00 PM
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Silvia Onesti (Elettra Sincrotrone Trieste)7/3/23, 2:00 PM
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Simone dal Zilio (CNR-IOM (Istituto Officina dei Materiali))7/3/23, 2:20 PM
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Marjetka Podobnik (NIC, Ljubljana)7/3/23, 2:40 PM
Integrated structural biology aims to provide high-resolution structural information about biological molecules and their complexes in isolated form or in biological context based on data obtained by various experimental and theoretical methods. This helps to understand biological processes and enables drug and vaccine discovery and other applications in biotechnology. For atomic resolution...
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Alfredo de Biasio (KAUST, Kingdom of Saudi Arabia )7/3/23, 3:10 PM
Cryo Electron Microscopy (cryo-EM) has revolutionized structure biology, allowing direct visualization of entire molecular machines at atomic resolution. In this talk, I will outline some of the applications of single-particle cryo-EM analysis we use in the lab to investigate the structure and function of enzymes operating in human DNA replication and repair.
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Alessio Ansuini (AREA Science Park)7/3/23, 3:40 PM
We review the current progress and challenges in the field of Machine Learning for Structural Biology. We will discuss existing machine learning algorithms such as AlphaFold for structural prediction, the use of large language models for protein design, and generative models applied to protein-protein docking. The aim of the seminar will be to encourage experts from relevant communities to...
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Paola Storici (Elettra Sincrotrone Trieste)7/3/23, 4:20 PM
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Kim Remans (EMBL Heidelberg)7/3/23, 4:50 PM
The goal of the EMBL Protein Expression and Purification Core Facility is to provide high-level services and advice regarding all aspects of protein expression, purification and characterisation. We aim to support our users with all individual steps of the workflow, going from the choice of the expression host organism and construct design to small scale screening, expression scale-up and...
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Opher Gileadi (SGC Karolinska)7/3/23, 5:20 PM
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