After 27 years of successfully serving the user community, Elettra is undertaking a major upgrade towards a diffraction limited light source, called Elettra 2.0, enabling new science and the development of new technologies to the general benefit.
Due to a substantial reduction of the emittance of the stored electron beam, the new machine will be able to host in particular also in-vacuum...
The new high brilliance microfocus μXRD beamline will be presented. μXRD aims to fullfill the needs of current XRD2 community and will open new opportunities to Elettra MX users.
i04-1 at Diamond Light Source is a fixed wavelength, high throughput beamline, dedicated to running unattended data collection queues. We utilise the beamtime to run XChem fragment screening experiments for both industry and academic users, allowing us on average to collect 2000 samples per week. In addition to what we require from the beamline, this talk will focus on the infrastructure...
Integrated structural biology aims to provide high-resolution structural information about biological molecules and their complexes in isolated form or in biological context based on data obtained by various experimental and theoretical methods. This helps to understand biological processes and enables drug and vaccine discovery and other applications in biotechnology. For atomic resolution...
Cryo Electron Microscopy (cryo-EM) has revolutionized structure biology, allowing direct visualization of entire molecular machines at atomic resolution. In this talk, I will outline some of the applications of single-particle cryo-EM analysis we use in the lab to investigate the structure and function of enzymes operating in human DNA replication and repair.
We review the current progress and challenges in the field of Machine Learning for Structural Biology. We will discuss existing machine learning algorithms such as AlphaFold for structural prediction, the use of large language models for protein design, and generative models applied to protein-protein docking. The aim of the seminar will be to encourage experts from relevant communities to...
The goal of the EMBL Protein Expression and Purification Core Facility is to provide high-level services and advice regarding all aspects of protein expression, purification and characterisation. We aim to support our users with all individual steps of the workflow, going from the choice of the expression host organism and construct design to small scale screening, expression scale-up and...
